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KMID : 0606320060230010050
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Journal of Phamacetical Sciences Sookmyung Women s University
2006 Volume.23 No. 1 p.50 ~ p.54
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Design and Synthesis of Novel Urea Analog as a PPAR Ligand
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Kim Yoon-Jung
Jeon Ra-Ok
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Abstract
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PPAR is one of the significant drug targets and activation of PPAR by several thiazolidinedione derivatives is well established. Herein bioisosteric replacement of thiazolidinedione to urea was carried out. Non-thiazolidinedione derivatives, [4-(2-carbazol-9-ylethoxy)phenyl]ureas (5,6) were designed and synthesized to obtain novel PPAR activators.
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